期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 17, 期 22, 页码 6107-6110出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.09.052
关键词
synthetic chelates; macrocyclic ligands; Cu-64; PET imaging; targeted radiotherapy; serum stability
资金
- Intramural NIH HHS [Z01 SC006353-24] Funding Source: Medline
- NCI NIH HHS [R01 CA112503, R01 CA112503-01A2] Funding Source: Medline
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA-Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with Cu-64, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA-Bn form stable complexes with Cu-64. (C) 2007 Elsevier Ltd. All rights reserved.
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