期刊
ANALYTICAL CHEMISTRY
卷 79, 期 22, 页码 8812-8815出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac0713858
关键词
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资金
- NCI NIH HHS [R33 CA105295] Funding Source: Medline
We report the use of desorption electrospray ionization hybrid Fourier transform ion cyclotron resonance mass spectrometry (DESI-FT-ICR-MS) for the analysis of carbohydrates. Spectra of neat carbohydrates are presented along with their mass measurement accuracies and limits of detection. Furthermore, a comparison is made between the analyses of O-linked glycans from mucin by DESI-FT-ICR-MS and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry. Finally, glycans from mucin are identified by using the high mass measurement accuracy and tandem MS capabilities afforded by the hybrid FT-ICR-MS platform.
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