期刊
VETERINARY MICROBIOLOGY
卷 125, 期 1-2, 页码 120-127出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.vetmic.2007.05.013
关键词
Actinobacillus pleuropneumoniae; RTX toxin; live attenuated vaccine
Previously, we reported the construction and characterization of a genetically defined Actinobacillus pleuropneumoniae (A. pleuropneumoniae) apxIIC gene mutant, 141304C(-), which conferred protection to mice against infection with A. pleuropneumoniae. In this study, we further evaluated HB04C(-) for safety and its ability to elicit protective immunity in pigs. It was demonstrated that a dose of 2 x 108 CFU HB04C(-) was safe to the pigs via intranasal or intramuscular injection. Immunization with a dose of 2 x 108 HB04C- by both intranasal and intramuscular routine could yield equal protective efficacy and elicited significant protection against experiment challenge with homologous or heterologous serotypes of a virulent A. pleuropneumonia. Taken together, HB04C- might serve as a promising vaccine candidate against infection with A. pleuropnetanoniae. (C) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据