期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 50, 期 23, 页码 5557-5560出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm7009777
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资金
- Intramural NIH HHS Funding Source: Medline
Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but caused rapid apoptosis. Unlike the parent compound, 7b is toxic to both p53 positive and negative cancer cells. It. has potent in vivo activity against xenografts of human colon and pancreatic tumors in athymic mice.
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