期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 60, 期 2, 页码 264-267出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2007.06.027
关键词
recombinant adeno-associated virus 2 (rAAV2); disaggregation; glycerol; atomic force microscope; dynamic light scattering
Preparation of distributed virus on a solid substrate is a prerequisite for investigation of the properties and individualism of virus, while many previous studies showed that virus has a tendency to aggregate on solid substrates. In this communication, we report a novel approach by which well-separated recombinant adeno-associated virus serotype 2 (rAAV2) could be prepared on bare mica surface. The key technique in this approach is the addition of less than 3% (v/v) glycerol into the virus solution and subsequently deposition onto mica surface for the sample preparation. The possible mechanisms are also briefly discussed. (C) 2007 Elsevier B.V. All rights reserved.
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