期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 156, 期 2, 页码 151-167出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2007.04.008
关键词
fMRI; borderline personality disorder; antisocial personality disorder; positive reinforcement; orbitofrontal cortex
资金
- MRC [G0300653, G9828266] Funding Source: UKRI
- Medical Research Council [G9828266, G0300653] Funding Source: researchfish
Decision making is guided by the likely consequences of behavioural choices. Neuronal correlates of financial reward have been described in a number of functional imaging studies in humans. Areas implicated in reward include ventral striatum, dopaminergic midbrain, amygdala and orbitofrontal cortex. Response to loss has not been as extensively studied but may involve prefrontal and medial temporal cortices. It has been proposed that increased sensitivity to reward and reduced sensitivity to punishment underlie some of the psychopathology in impulsive personality disordered individuals. However, few imaging studies using reinforcement tasks have been conducted in this group. In this MRI study, we investigate the effects of positive (monetary reward) and negative (monetary loss) outcomes on BOLD responses in two target selection tasks. The experimental group comprised eight people with Cluster B (antisocial and borderline) personality disorder, whilst the control group contained fourteen healthy participants. A key finding was the absence of prefrontal responses and reduced BOLD signal in the subcortical reward system in the PD group during positive reinforcement. Impulsivity scores correlated negatively with prefrontal responses in the PD but not the control group during both, reward and loss. Our results suggest dysfunctional responses to rewarding and aversive stimuli in Cluster B personality disordered individuals but do not support the notion of hypersensitivity to reward and hyposensitivity to loss. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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