期刊
CANCER LETTERS
卷 257, 期 2, 页码 199-205出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2007.07.018
关键词
RASSF1A; esophageal cancer; nasopharyngeal carcinoma; tissue microarray
类别
资金
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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