Remotely triggered release from magnetic nanoparticles

Multifunctional nanoparticles are multivalent, remotely-actuated, and imaged non-invasively. Superparamagnetic nanoparticles transduce external electromagnetic energy to heat, thereby melting oligonucleotide duplexes that act as tunable, heat-labile tethers to release model drugs in vivo (see figure).