期刊
VACCINE
卷 25, 期 47, 页码 8077-8084出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2007.09.026
关键词
Japanese encephalitis virus; T-lymphocyte epitopes; epitope mapping
T-cell epitope variability is associated with viral immune escape and may influence the outcome of vaccination against the highly variable Japanese Encephalitis Virus (JEV). We computationally analyzed the ChimeriVax-JEV vaccine envelope sequence for T helper epitopes that are conserved in 12 circulating JEV strains and discovered 75% conservation among putative epitopes. Among non-identical epitopes, only minor amino acid changes that would not significantly affect HLA-binding were present. Therefore, in most cases, circulating strain epitopes could be restricted by the same HLA and are likely to stimulate a cross-reactive T-cell response. Based on this analysis, we predict no significant abrogation of ChimeriVax-JEV-conferred protection against circulating JEV strains. (c) 2007 Elsevier Ltd. All rights reserved.
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