期刊
WORLD JOURNAL OF GASTROENTEROLOGY
卷 13, 期 43, 页码 5731-5735出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.3748/wjg.v13.i43.5731
关键词
Mycobacterium avium subspecies Paratuberculosis; enteric glial cells; inflammatory bowel diseases; Crohn's disease; sigma factors expression
AIM: To establish the role of enteric glial cells during infection with Mycobacterium avium subspecies paratuberculosis (MAP) in Crohn's disease. METHODS: In order to establish the role of enteric glial cells during infection with M. avium subspecies paratuberculosis (MAP) in Crohn's disease, Map adhesion experiments on enteric glial cells were performed as well as expression analysis of Map sigma factors during infection. RESULTS: In this study, for the first time, we found a high affinity of MAP to enteric glial cells and we analyzed the expression of MAP sigma factors under different conditions of growth. CONCLUSION: The fact that Map showed a high affinity to the glial cells raises concerns about the complicated etiology of the Crohn's disease. Elucidation of the mechanisms whereby inflammation alters enteric neural control of gut functions may lead to novel treatments for Crohn's disease. (C) 2007 WJG. All rights reserved.
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