期刊
VIROLOGY
卷 368, 期 2, 页码 227-231出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2007.08.030
关键词
herpes simplex virus; herpetic stromal keratitis; vaccine; latency
类别
资金
- NIAID NIH HHS [R01 AI057552-03, R01 AI057552-01A1, AI57552, R56 AI057552, R01 AI057552, R01 AI057552-02] Funding Source: Medline
Ocular infections with herpes simplex virus 1 can lead to corneal scarring and blindness, with herpes keratitis being the major infectious cause of blindness. There is currently no clinically approved vaccine and nearly all developmental vaccines are targeted against HSV-2 and genital herpes. We tested the ability of an HSV-2 replication-defective virus, a genital herpes vaccine candidate, to protect against HSV-1 corneal infection. Immunization with HSV-2 dl5-29 reduced viral replication in the cornea, prevented ocular disease and reduced latent infection by the HSV-1 strain. Therefore, this HSV-2 replication-defective mutant strain may have applications for prevention of herpes keratitis and genital herpes due to HSV-1 infection. (c) 2007 Elsevier Inc. All rights reserved.
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