期刊
TETRAHEDRON
卷 63, 期 48, 页码 11886-11892出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2007.09.027
关键词
organocatalysis; aldol reactions; NOBIN; prolinamides
(S)-NOBIN-L-prolinamide was employed as organocatalyst in the direct aldol reactions of different ketones and aromatic aldehydes using dioxane as solvent and in the presence of water as additive. Acetone led to the aldol products in up to 93% ee, while cyclic ketones furnished the anti-aldols in moderate to high yield, excellent diastereoselectivity (up to > 99/< 1 anti/syn ratio) and high ee (up to 95%). (c) 2007 Elsevier Ltd. All rights reserved.
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