期刊
AQUACULTURE
卷 272, 期 1-4, 页码 180-187出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquaculture.2007.08.049
关键词
Scylla serrata; enrofloxacin; metabolite; ciprofloxacin; salinity; pharmacokinetics
The pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in the mud crab (Scylla serrata) kept at two salinities of 4 ppt and 33 ppt after a single oral gavage of 30 mg enrofloxacin per kg body weight. The concentrations of enrofloxacin and ciprofloxacin in the main tissues (hemolymph, muscle and hepatopancreas) were simultaneously detected by HPLC. The parameters in hemolymph and tissues were calculated by non-compartment model based on statistic moment theory. Area under the concentration-time curve from 0 to infinity h (AUC(0-infinity)), apparent volume of distribution (Vz), half-life (t(1/2)z)), body clearance (CLz) and mean residue time from 0 to infinity h (MRT(0-infinity)) in hemolymph were 1628.6 mu gh/ml, 1.73 L/kg, 65.09 h, 0.018 U h/kg and 83.72 h, respectively, at 4 ppt, and 3251.4 mu gh/ml, 1.547 L/kg, 116.22 h, 0.009 L/h/kg and 160.66 h, respectively, at 33 ppt. Peak levels of enrofloxacin in hepatopancreas were much higher than those in the hemolymph and muscle, at both salinities. Comparative pharmacokinetics in hemolymph, muscle and hepatopancreas showed slower elimination of enrofloxacin at 33 ppt than at 4 ppt. The AUC ratios of ciprofloxacin and enrofloxacin in mud crab hemolymph at 4 ppt and 33 ppt were only 4.0% and 3.8%, respectively. Mean residue time (MRT) and body clearance (CLz), deriving from statistical moment theory, indicated that ciprofloxacin eliminated slower at 33 ppt than at 4 ppt, the same as enrofloxacin. (c) 2007 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据