期刊
FEBS LETTERS
卷 581, 期 28, 页码 5511-5516出版社
WILEY
DOI: 10.1016/j.febslet.2007.10.061
关键词
Lands cycle; Acyl-CoA : lysophosphatidylcholine; acyltransferase; PC turnover; Saccharomyces cerevisiae
Cellular phospholipids undergo deacylation and reacylation through a process known as Lands cycle. In this report, we provide evidence demonstrating that yeast YOR175c, herein designated as LCA1, encodes a key component of the Lands cycle, the acyl-CoA: lysophosphatidylcholine acyltransferase (LPCAT). Deletion of LCA1 resulted in a drastic reduction in LPCAT activity, while over expression led to a several fold increase in enzyme activity. We further show that disruption of LCA1 caused an enhanced production of glycerophosphorylcholine, a product of phosphatidylcholine (PC) deacylation and that the lysophosphatidic acid acyltransferase SLC1 was not involved in this process. Identification of LCA1 provides an essential molecular tool for further study of Lands cycle in PC turnover. (C) 2007 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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