期刊
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
卷 17, 期 12, 页码 2528-2537出版社
IOP PUBLISHING LTD
DOI: 10.1088/0960-1317/17/12/020
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We present a MEMS sensor aiming to enable continuous monitoring of glucose levels in diabetes patients. The device features a magnetically-driven vibrating microcantilever, which is situated in a microchamber and separated from the environment by a semi-permeable membrane. Glucose sensing is based on affinity binding principles using a solution of dextran concanavalin-A ( Con A) as the sensing fluid. The glucose concentration is determined by detecting viscosity changes induced by the binding of glucose to Con A through the measurement of the cantilever's vibration parameters. The device is capable of measuring physiologically relevant glucose concentrations from 0 to 25 mM with a resolution better than 0.025 mM and a phase sensitivity better than 0.4 degrees mM(-1). The response of the sensor to glucose concentration changes has a time constant down to 4.27 min, and can be further improved with optimized device designs.
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