期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 51, 期 12, 页码 4495-4497出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00753-07
关键词
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资金
- NIAID NIH HHS [AI49485, R01 AI049485, AI44063, R01 AI044063] Funding Source: Medline
Diethyldithiocarbamate (DETC) and pyrrolidine dithiocarbamate (PDTC) were highly active against tubercle bacilli, with MICs of 8 mu g/ml and 0.13 mu g/ml, respectively. DETC and PDTC were active against old cultures, enhanced pyrazinamide or pyrazinamide/rifampin activity, and had serum inhibitory titers of 1:2 and 1:4, respectively, in mice given 100 mg/kg orally.
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