期刊
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
卷 20, 期 4, 页码 571-596出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beha.2007.08.004
关键词
genetics; gene expression profiling; molecular pathogenesis; prognosis; IgH translocations; hyperdiploid
类别
资金
- NCI NIH HHS [P50 CA100707-010004, K01 CA074265-05, P50 CA100707, K01 CA074265-03, K01 CA074265-04] Funding Source: Medline
- NIA NIH HHS [R01 AG020686-04, R01 AG020686-01A1, R01 AG020686, R01 AG020686-03, R01 AG020686-05, R01 AG020686-02] Funding Source: Medline
The genetics of myeloma has been increasingly elucidated in recent years. Recurrent genetic events, and also biologically distinct and clinically relevant genetic subtypes of myeloma have been defined. This has facilitated our understanding of the molecular pathogenesis of the disease. In addition, some genetic abnormalities have proved to be highly reproducible prognostic factors. With the expanding therapeutic armamentarium, it is time to include genetic assessment as part of clinical evaluation of myeloma patients to guide management. In this review we examine the role of various genetic abnormalities in the molecular pathogenesis of myeloma, and the use of such abnormalities in disease classification, prognosis and clinical management.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据