期刊
CURRENT OPINION IN NEUROLOGY
卷 20, 期 6, 页码 667-673出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0b013e3282f1c6fa
关键词
anomia; aphasia; functional neuroirnaging; recovery; treatment
资金
- Wellcome Trust Funding Source: Medline
Purpose of review In this review of papers published between May 2006 and May 2007, we discuss functional neuroimaging studies of recovery and treatment of patients with aphasia after stroke. Recent findings Studies of recovery of aphasia have highlighted the importance of right inferior frontal gyrus activation, especially early after stroke, when it correlates with language recovery. In contrast, in the later stages after stroke left hemisphere activations predict chronic aphasia; speech production recovery appears to depend on left frontal activation, whereas speech comprehension depends on left temporal activation. There have been few studies of treatment of aphasia, but preliminary evidence suggests that treatment of speech production difficulties, even years after stroke, may be effective and deserves further study. Summary Recent studies of aphasia recovery allow a deeper appreciation of the changing neuronal activation patterns associated with time after stroke. The distinction between neuronal reorganization that does and does not sustain recovery in the chronic phase after stroke, either spontaneous or in response to treatment, remains controversial and further studies are necessary. Clinical diagnosis and treatment of aphasia requires many more longitudinal studies with larger patient numbers and more detailed behavioural and lesion characterization of stroke patients.
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