期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 90, 期 6, 页码 1074-1081出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.13-0391
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资金
- National Institutes of Health Tropical Medical Research Center [P50 AI074285]
- National Institutes of Health Fogarty Scholars Program [R24 TW007988]
- MRC [MR/K007467/1] Funding Source: UKRI
- Medical Research Council [MR/K007467/1] Funding Source: researchfish
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major cause of morbidity and mortality in Central and South America. Geographic variations in the sensitivity of serologic diagnostic assays to T. cruzi may reflect differences in T cruzi exposure. We measured parasite-specific T-cell responses among seropositive individuals in two populations from South America with widely varying antibody titers against T. cruzi. Antibody titers among seropositive individuals were significantly lower in Arequipa, Peru compared with Santa Cruz, Bolivia. Similarly, the proportion of seropositive individuals with positive T-cell responses was lower in Peru than Bolivia, resulting in overall lower frequencies of interferon-gamma (IFN gamma)-secreting cells from Peruvian samples. However, the magnitude of the IFN gamma response was similar among the IFN gamma responders in both locations. These data indicate that immunological discrepancies based on geographic region are reflected in T-cell responses as well as antibody responses.
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