期刊
BRAIN IMAGING AND BEHAVIOR
卷 1, 期 3-4, 页码 43-57出版社
SPRINGER
DOI: 10.1007/s11682-007-9004-1
关键词
fMRI; Smoking; Tobacco; Cue reactivity; Ventral striatum; Nucleus accumbens
类别
资金
- Public Health Service, National Institute on Drug Abuse/National Institutes of Health [K08 DA14276]
- Cancer Research UK
- Centre for Functional Neuroimaging of the Brain (FMRIB), Medical Research Council
- MRC [G9409531, G9409634] Funding Source: UKRI
- Medical Research Council [G9409634, G9409531] Funding Source: researchfish
To achieve greater understanding of the brain mechanisms underlying nicotine craving in female smokers, we examined the influence of nicotine non-abstinence vs. acute nicotine abstinence on cue-elicited activation of the ventral striatum. Eight female smokers underwent an event-related functional magnetic resonance imaging (fMRI) paradigm presenting randomized sequences of smoking-related and non-smoking related pictures. Participants were asked to indicate by a key press the gender of individuals in smoking-related and non-smoking related pictures (gender discrimination task), to maintain and evaluate attention to the pictures. There was a significant effect of smoking condition on reaction times (RT) for a gender discrimination task intended to assess and maintain attention to the photographs-suggesting a deprivation effect of acute nicotine abstinence and a statistical trend indicating greater RTs for smoking cues than neutral cues. BOLD contrast (smoking vs. non-smoking cues) was greater in the non-abstinent vs. acutely abstinent conditions in the ventral striatum including the nucleus accumbens (VS/NAc). Moreover, a significant positive correlation was observed between baseline cigarette craving prior to scanning and VS/NAc activation (r = 0.84, p = 0.009), but only in the non-abstinent condition. These results may either be explained by ceiling effects of nicotine withdrawal in the abstinent condition or, may indicate reduced relative activation (smoking vs. neutral contrast) in the VS/NAc in the abstinent vs. non-abstinent conditions in this group of female smokers.
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