期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 89, 期 5, 页码 996-1000出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.13-0232
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资金
- National Institutes of Health, National Institute of Allergy and Infectious Diseases [K23 AI057341, AI U19 089992, N01 50027 HHSN266200500027C, 5R01AI091816-01]
- Department of Defense/Army [W81XWH-04-2-0031]
- Gillson Longenbaugh Foundation
In Houston, we have been monitoring the immune response to West Nile virus (WNV) infection in a large cohort of study participants since 2002. Using enzyme-linked immunosorbent assay techniques, serum from 163 participants was tested for the presence of anti-WNV immunoglobulin M (IgM) and IgG antibodies. We found that 42%, 34%, and 23% of study participants had either positive or equivocal results when tested for anti-WNV IgM antibodies approximately 1, 6, and 8 years post-infection, respectively. Conversely, almost one-half of study participants (46%) had undetectable anti-WNV IgG antibodies by 8 years post-infection. This study is the first study to calculate the slope of the rate of decay of antibodies over time as well as show persistence of detectable anti-WNV IgM antibodies up to 8 years post-infection. These findings warrant additional investigation, particularly the determination of whether persistence of IgM is related to persistent infection with WNV.
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