期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 89, 期 4, 页码 654-664出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.13-0208
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To assess the spectrum of illness from toxigenic Vibrio cholerae 01 and risk factors for severe cholera in Haiti, we conducted a cross-sectional survey in a rural commune with more than 21,000 residents. During March 22-April 6, 2011, we interviewed 2,622 residents >= 2 years of age and tested serum specimens from 2,527 (96%) participants for vibriocidal and antibodies against cholera toxin; 18% of participants reported a cholera diagnosis, 39% had vibriocidal titers >= 320, and 64% had vibriocidal titers >= 80, suggesting widespread infection. Among seropositive participants (vibriocidal titers >= 320), 74.5% reported no diarrhea and 9.0% had severe cholera (reported receiving intravenous fluids and overnight hospitalization). This high burden of severe cholera is likely explained by the lack of pre-existing immunity in this population, although the virulence of the atypical El Tor strain causing the epidemic and other factors might also play a role.
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