期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 88, 期 6, 页码 1146-1151出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.12-0464
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资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, Argentina)
- Secretaria de Ciencia y Tecnologia de la Universidad Nacional de Cordoba, Argentina
Flight muscles of Triatoma infestans have two glycerol-3-phosphate dehydrogenase (GPDH) isoforms: GPDH-1 is involved in flight metabolism and GPDH-2 provides lipid precursors. Total GPDH activity was greater in the natural population and almost only due to GPDH-1. Different expression and activity observed between GPDH isoforms in the natural population and the first laboratory generation was not detected in the second laboratory generation. This pattern may be caused by gradual adaptation to laboratory nutritional conditions. During development, the expression of GPDH-2 increased with a longer time of intake, which would imply an increment in lipid biosynthesis. The GPDH-1 transcript predominated with respect to that of GPDH-2 in the lower nutritional condition, suggesting the necessity of insects to fly during this nutritional status. The transcriptional pattern showed a delay at 22 degrees C. The isoforms activities and transcript patterns in flight muscles suggest transcriptional adaptation to metabolic requirements originated by alternative splicing.
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