期刊
TRENDS IN GENETICS
卷 23, 期 12, 页码 605-613出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.09.004
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资金
- Intramural NIH HHS Funding Source: Medline
- NIDCR NIH HHS [U01-DE017018, R01-DE16558] Funding Source: Medline
- NINDS NIH HHS [P01 NS045685] Funding Source: Medline
Pain is emotionally detrimental and consciously avoided; however, it is absolutely crucial for our survival. Pain perception is one of the most complicated measurable traits because it is an aggregate of several phenotypes associated with peripheral and central nervous system dynamics, stress responsiveness and inflammatory state. As a complex trait, it is expected to have a pollygenic nature shaped by environmental pressures. Here we discuss what is known about these contributing genetic variants, including recent discoveries that show a crucial role of voltage-gated sodium channel Nav1.7 in pain perception and how we can advance our understanding of the pain genetic network. We propose how both rare deleterious genetic variants and common genetic polymorphisms are mediators of human pain perception and clinical pain phenotypes.
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