Outcome of in vitro fertilization treatment in infertile women conservatively treated for endometrial adenocarcinoma

Objective: To evaluate IVF characteristics and outcome of infertile women conservatively treated for well-differentiated endometrial adenocarcinoma. Design: Observational case series study. Setting: The Department of Gynecology Oncology and IVF unit of Chaim Sheba Medical center, Tel-Hashomer, Israel. Patient(s): Eight women referred to IVF treatment because of failure of other fertility treatments after conservative treatment of endometrial adenocarcinoma. All women were selected carefully for conservative treatment at the Department of Gynecology Oncology of the Chaim Sheba Medical Center after a thorough metastatic workup. Intervention(s): In vitro fertilization/intracytoplasmic sperm injection treatment. Main Outcome Measure(s): Serum E-2 levels at hCG administration, endometrial thickness, number of oocytes retrieved, fertilization rate, pregnancy and delivery rate. Result(S): All women were nulliparous before IVF treatment, and only one woman was older than 35 years. In four of them, endometrial adenocarcinoma was diagnosed during infertility workup, or treatment. A total of 31 IVF cycles were performed. The mean number of oocytes retrieved was 9.4 (95% confidence interval, 5.1-13.6), and fertilization rate was 58.6%. Six women (75%) conceived, and four (50%) delivered six healthy offspring. Conclusion(s): In vitro fertilization treatment of infertile women conservatively treated for well -differentiated endometrial adenocarcinoma is highly successful and offers the opportunity to cryopreserve embryos for future use. (Fertil Steril((R)) 2007;88:1562-7. (c) 2007 by American Society for Reproductive Medicine.).