期刊
INORGANICA CHIMICA ACTA
卷 360, 期 15, 页码 4093-4102出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2007.05.042
关键词
quinolones; N-propyl-norfloxacin; pipemidic acid; copper(II) complexes; interaction with calf-thymus DNA; MIC
The neutral mononuclear copper(II) complexes with the quinolone antibacterial drugs, pipemidic acid and N-propyl-norfloxacin, in the presence or absence of nitrogen-donor heterocyclic ligands, 2,2'-bipyridine, 1,10-phenanthroline or 2,2'-dipyridylamine, have been prepared and characterized spectroscopically. The interaction of copper(II) with the deprotonated quinolone ligand leads to the formation of the neutral mononuclear complexes of the type [Cu(quinolone)(2)(H2O)] (1)-(2) while the presence of the N-donor ligand leads to the formation of the neutral mononuclear complexes of the type [Cu(quinolone)(N-donor)Cl] (3)-(8). In all the complexes, copper(II) is pentacoordinate having a distorted square pyramidal geometry. The electron paramagnetic resonance spectra of 1 and 2 are typical of mononuclear Cu(II) complexes, while for the mixed-ligands complexes 3-8 a mixture of dimeric and monomeric species is indicated. The interaction of the complexes with calf-thymus DNA has been investigated with diverse spectroscopic techniques and has shown that the complexes can be bound to calf-thymus DNA by the intercalative mode. The antimicrobial activity of the complexes has been tested on three different microorganisms. All the complexes show an increased biological activity in comparison to the corresponding free quinolone ligand. (C) 2007 Elsevier B.V. All rights reserved.
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