期刊
MAGNETIC RESONANCE IN MEDICINE
卷 58, 期 6, 页码 1276-1282出版社
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.21383
关键词
GABA; brain; magnetic resonance spectroscopy; 3 Tesla; MEGA-PRESS
资金
- NCRR NIH HHS [P41 RR15241] Funding Source: Medline
The MEGA-PRESS-IVS method has been developed, which combines MEGA (a frequency-selective editing technique) editing with the point-resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing the deleterious effects of spatial variation in coupling evolution. The IVS method has been previously described for improved efficiency of lactate detection. The current study demonstrates that the combination of MEGA-PRESS with IVS results in increased sensitivity for edited single-voxel measurements of glutamate and gamma-aminobutyric acid (GABA). A four-compart- ment model of coupling evolution is investigated through simple product operators and full spin-system simulations and the predicted pattern of signal evolution is demonstrated through MEGA-PRESS-MRSI. MEGA-PRESS-IVS is then compared to MEGA-PRESS in a phantom and an average signal increase of 24% is demonstrated in five healthy volunteers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据