期刊
AUTOIMMUNITY REVIEWS
卷 7, 期 2, 页码 114-120出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2007.02.019
关键词
B-cells; cryoglobulinemia; autoitamunity; HCV; lymphoma; thyroid; diabetes
类别
Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients. (C) 2007 Elsevier B.V. All rights reserved.
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