期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 86, 期 5, 页码 884-894出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2012.11-0342
关键词
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资金
- Science and Technology Directorate, Department of Homeland Security
- Fogarty International Center, National Institutes of Health
- Centers for Disease Control and Prevention [U01EH000418]
- National Institutes of Allergy and Infectious Diseases, National Institues of Health [R01 AI55607]
Temperature has played a critical role in the spatiotemporal dynamics of West Nile virus transmission throughout California from its introduction in 2003 through establishment by 2009. We compared two novel mechanistic measures of transmission risk, the temperature-dependent ratio of virus extrinsic incubation period to the mosquito gonotrophic period (BT), and the fundamental reproductive ratio (R-0) based on a mathematical model, to analyze spatiotemporal patterns of receptivity to viral amplification. Maps of BT and R-0 were created at 20-km scale and compared throughout California to seroconversions in sentinel chicken flocks at half-month intervals. Overall, estimates of BT and R-0 agreed with intensity of transmission measured by the frequency of sentinel chicken seroconversions. Mechanistic measures such as these are important for understanding how temperature affects the spatiotemporal dynamics of West Nile virus transmission and for delineating risk estimates useful to inform vector control agency intervention decisions and communicate outbreak potential.
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