期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 87, 期 5, 页码 822-831出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2012.12-0251
关键词
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资金
- Pfizer Animal Health/Morris Animal Foundation Veterinary Fellowship for Advanced Degrees
- NEWAID Foundation Fellowship for Research in Neglected Tropical Disease
- National Institutes of Health [1 R21 AI088051-01]
Visceral leishmaniasis (VL), caused by Leishmania infantum chagasi (L.i. chagasi syn. infantum) in north-eastern Brazil, was responsible for 51,000 new VL cases from 1980 to 2003. Household presence of L. infantum-infected dogs is a major risk factor for human infection. Despite culling of dogs based on seropositivity, canine L. infantum seroprevalence remains near 20%, suggesting that dog culling is ineffective for preventing VL spread. We administered a cross-sectional survey to 224 households within 300 m of the homes of VL human patients diagnosed within the last year. The goal was to develop a model for voluntary preventative use based on characteristics and motivations of dog owners. We identified that owner knowledge deficiencies regarding canine transmission of L. infantum associated with increased risk of dog infection (odds ratio [OR] = 3.681, confidence interval [CI] = 1.223, 11.08). Higher owner education was associated with decreased levels of dog seropositivity (OR = 0.40, CI = 0.20, 0.81). Pet attachment (P = 0.036) and perception of risk/disease knowledge (P = 0.040) were significantly associated with willingness to voluntarily purchase canine VL prevention. These results highlight the importance of owner attachment to their pet in implementing reservoir-targeted zoonotic VL prevention.
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