期刊
NATURE REVIEWS CANCER
卷 7, 期 12, 页码 911-924出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2249
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- NCI NIH HHS [R01 CA090522, R01 CA095925] Funding Source: Medline
Chromosome instability, which is equated to mitotic defects and consequential chromosome segregation errors, provides a formidable basis for the acquisition of further malignant phenotypes during tumour progression. Centrosomes have a crucial role in the formation of bipolar mitotic spindles, which are essential for accurate chromosome segregation. Mutations of certain oncogenic and tumour-suppressor proteins directly induce chromosome instability by disrupting the normal function and numeral integrity of centrosomes. How these proteins control centrosome duplication and function, and how their mutational activation and/or inactivation results in numeral and functional centrosome abnormalities, is discussed in this Review.
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