期刊
CHEST
卷 132, 期 6, 页码 1906-1912出版社
ELSEVIER
DOI: 10.1378/chest.07-1246
关键词
MRI; prognosis; pulmonary arterial hypertension; pulmonary artery stiffness
Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. M ethods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 +/- 214 mm(2) vs 411 +/- 153 mm(2), p < 0.001), less distensible (area distensibility = 0.46 +/- 0.38.10(-2) mm Hg-1 vs 3.69 +/- 1.96.10(-2) mm Hg-1, p < 0.0001), and RAC was smaller (20 +/- 10% vs 58 +/- 21%, p < 0.0001) [mean SD]. RAC showed an inverse curvilinear relation with mean pulmonary artery pressure (R-2 = 0.47). Eighteen patients (26%) died because of cardiopulmonary causes. Patients with a pulmonary artery RAC <= 16% had a worse prognosis than those with a value > 16% (log-rank p < 0.001). RAC predicted mortality better than area distensibility. Conclusion: Noninvasively measured pulmonary artery RAC predicts mortality in patients with PAH.
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