期刊
PSYCHOLOGICAL MEDICINE
卷 37, 期 12, 页码 1703-1715出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291707000815
关键词
-
资金
- Medical Research Council [G0300189, G9817803B] Funding Source: researchfish
- Medical Research Council [G0300189] Funding Source: Medline
- NIMH NIH HHS [R01MH062873, R01 MH062873] Funding Source: Medline
- MRC [G0300189] Funding Source: UKRI
Background. Reaction time (RT) variability is one of the strongest findings to emerge in cognitive-experimental research of attention deficit hyperactivity disorder (ADHD). We set out to confirm the association between ADHD and slow and variable RTs and investigate the degree to which RT performance improves under fast event rate and incentives. Using a group familial correlation approach, we tested the hypothesis that there are shared familial effects on RT performance and ADHD. Method. A total of 144 ADHD combined-type probands, 125 siblings of the ADHD probands and 60 control participants, ages 6-18, performed a four-choice RT task with baseline and fast-incentive conditions. Results. ADHD was associated with slow and variable RTs, and with greater improvement in speed and RT variability from baseline to fast-incentive condition. RT performance showed shared familial influences with ADHD. Under the assumption that the familial effects represent genetic influences, the proportion of the phenotypic correlation due to shared familial influences was estimated as 60-70 %. Conclusions. The data are inconsistent with models that consider RT variability as reflecting a stable cognitive deficit in ADHD, but instead emphasize the extent to which energetic or motivational factors can have a greater effect on RT performance in ADHD. The findings support the role of RT variability as an endophenotype mediating the link between genes and ADHD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据