期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 85, 期 4, 页码 750-757出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2011.11-0359
关键词
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资金
- National Science Foundation
- National Security Education Program David L. Boren Fellowship
- Naval Medical Research Center Detachment Work Unit [800000.82000.25GB.B0016]
- National Institutes of Health [N01-AI25489]
Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log(10) and 7.3 log(10) plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log(10) PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.
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