期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 1, 页码 152-157出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0578
关键词
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资金
- Spanish Agency for International Cooperation
- Center for Vaccine Development, University of Maryland
- Fondo de Investigaciones Sanitarias [CP05/0130, PI06/0204]
Antibiotic resistance in Africa is increasing but insufficiently recognized as a public health problem. However, there are scarce data for antimicrobial resistance trends among bloodstream isolates in sub-Saharan Africa. Antimicrobial drug resistance trends among bacteria isolated from blood of children <15 years of age admitted to the Manhica District Hospital in Mozambique during May 2001 April 2006 were monitored by disk diffusion. We documented a linear trend of increasing resistance throughout the study period to chloramphenicol among isolates of Non-typhi Salmonella (P < 0.001), Escherichia coli (P = 0.002), Staphylococcus aureus (P < 0.001), and Haemophilus influenzae (P < 0.001). Increasing resistance to ampicillin was also observed for H. influenzae isolates (P < 0.001). We report trends of increasing resistance among the most frequent etiologies of bacteremia to the most commonly used antibiotics for empirical therapy in this community. Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections.
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