期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 82, 期 2, 页码 185-193出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.08-0580
关键词
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资金
- Research Foundations of Sao Paulo (FAPESP)
- Minas Gerais (FAPEMIG) States
- Brazilian National Research Council (CNPq)
- Oswaldo Cruz Foundation (PAPES IV/FIOCRUZ)
Duffy binding protein (DBP), a leading malaria vaccine candidate, plays a critical role ill Plasmodium vivax erythrocyte invasion. Sixty-eight of 366 (18.6%) subjects had IgG anti-DBP antibodies by enzyme-linked immunosorbent assay (ELISA) in a community-based cross-sectional survey ill the Brazilian Amazon Basin. Despite Continuous exposure to low-level malaria transmission, the overall seroprevalence decreased to 9.0% when the Population was reexamined 12 months later. Antibodies from 16 of 50 (360%) Subjects who were ELISA-positive at the baseline were able to inhibit erythrocyte binding to at least one of two DBP variants tested. Most (13 of 16) of these subjects still had inhibitory antibodies when reevaluated 12 months later. Cumulative exposure to malaria was the strongest predictor of DBP seropositivity identified by Multiple logistic regression models in this population. The poor antibody recognition of DBP elicited by natural exposure to P. vivax in Amazonian populations represents a challenge to be addressed by vaccine development strategies.
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