期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 82, 期 2, 页码 330-336出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0542
关键词
-
资金
- National Institutes of Health [U01 AI065654]
Infants are a vulnerable and unique Population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses, Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.
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