期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 1, 页码 115-121出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0684
关键词
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资金
- Institut de Recherche pour le Developpement (IRD) (Departement Soutien et Formation)
- Research Ministry of France
- Francois Lacoste
- Inkerman Foundation
- Acer-Energy (ACERGY)-Societe Nationale de Metallurgic (SONAMET) Company
- French Ministry of Defense (Delegation Generale pour l'Armement, DGA)
For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.
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