期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 5, 页码 1044-1047出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.10-0326
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资金
- French Institut de Recherche pour le Developpement
- French Institut de Medecine et d Epidemiologie Appliquee [IMEA 0201]
Vector control has led to a drastic decrease in the prevalence of acquired Chagas disease in Latin America thus redirecting attention to congenital Chagas disease We report results of a longitudinal study of 359 pregnant women in Yacuiba in southern Bolivia, of whom 147 (40 9%) were infected with Trypanosoma cruzi, to evaluate the relation ship between the patency period of the parasitemia and the risk of congenital infection Maternal infection was assessed by using T cruzi-specific serologic tests and parasitemia in mothers and newborns was diagnosed by using microscopic examination of blood in heparinized microhematocrit tubes Parasitemia was present in 28 6% of the infected women Its prevalence increased during the third trimester then decreased at delivery The likelihood of congenital infection was significantly correlated with the parasite density in the mother s blood The risk of transmission increased during the third trimester of pregnancy and could explain premature births or low weight newborns for infected mothers
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