期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 2, 页码 388-394出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.09-0688
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资金
- Tulane University Department of Tropical Medicine and CDC Cooperative Agreement [T01/CCT622308-02]
- Louisiana Vaccine Center
- South Louisiana Institute for Infectious Disease Research
- Louisiana Board of Regents
Acute febrile illnesses comprise the majority of the human disease burden in sub-Saharan Africa We hypothesized that arboviruses comprised a considerable proportion of undiagnosed febrile illnesses in Guinea and sought to determine the frequency of arboviral disease in two hospitals there. Using a standard case definition, 47 suspected cases were detected in approximately 4 months Immunoglobulin M antibody capture enzyme-linked immunosorbent assays and plaque-reduction neutralization assays revealed that 63% (30/47) of patients were infected with arboviruses. including 11 West Nile. 2 yellow fever, 1 dengue, 8 chikungunya. and 5 Tahyna infections. Except for yellow fever, these are the first reported cases of human disease from these viruses in Guinea and the first reported cases of symptomatic Tahyna infection in Africa These results strongly suggest that arboviruses circulate and are common causes of disease in Guinea Improving surveillance and laboratory capacity for arbovirus diagnoses will be integral to understanding the burden posed by these agents in the region.
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