期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 83, 期 6, 页码 1212-1220出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2010.10-0264
关键词
-
资金
- Academy of Finland [79787, 207010]
- Foundation for Pediatric Research in Finland
- Tampere University Hospital
- Pfizer Inc (New York, NY)
- Academy of Finland (AKA) [79787, 207010, 79787, 207010] Funding Source: Academy of Finland (AKA)
Preterm delivery, which is associated with infections during pregnancy, is common in sub-Saharan Africa. We enrolled 1,320 pregnant women into a randomized, controlled trial in Malawi to study whether preterm delivery and low birth weight (LBW) incidence can be reduced by intermittent preventive treatment of maternal malaria and reproductive tract infections. The participants received either sulfadoxine-pyrimethamine (SP) twice (controls), monthly SP, or monthly SP and two doses of azithromycin (AZI-SP). The incidence of preterm delivery was 17.9% in controls, 15.4% in the monthly SP group (P = 0.32), and 11.8% in AZI-SP group (risk ratio = 0.66, P = 0.01). Compared with controls, those in AZI-SP group had a risk ratio of 0.61 (P = 0.02) for LBW. Incidence of serious adverse events was low in all groups. In conclusion, the incidence of preterm delivery and LBW can in some conditions be reduced by treating pregnant women with monthly SP and two azithromycin doses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据