期刊
EXPERIMENTAL AND MOLECULAR PATHOLOGY
卷 83, 期 3, 页码 283-295出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yexmp.2007.08.014
关键词
CD147; EMMPRIN; MMP; MCT; immunoglobulin superfamily; integrin; tumor; metastasis
类别
资金
- NINDS NIH HHS [R01 NS048503-04, R01 NS048503] Funding Source: Medline
The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal, lymphocyte and extracellular matrix development. Here we review the current understanding of CD147 expression and protein interactions with regard to CD147 function and its role in pathologic conditions including heart disease, Alzheimer's disease, stroke and cancer. A model linking hypoxic conditions found within the tumor microenvironment to upregulation of CD147 expression and tumor progression is introduced. (c) 2007 Elsevier Inc. All rights reserved.
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