期刊
SEMINARS IN IMMUNOLOGY
卷 19, 期 6, 页码 409-417出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2007.10.011
关键词
Th17; IL-17; ROR gamma t; mucosal immunity; regulatory T cells
类别
资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI033856-14, R01 AI033856] Funding Source: Medline
The paradigm of effector T helper cell differentiation into either Th1 or Th2 lineages has been profoundly shaken by the discovery of T cells that secrete IL-17 and other inflammatory cytokines. This subset, referred to as Th17, is centrally involved in autoimmune disease and is important in host defense at mucosal surfaces. In mouse, a series of cytokines, including IL-6, IL-21, IL-23, and TGF-beta, function sequentially or synergistically to induce the Th17 lineage. Other cytokines, including IL-2, IL-4, IFN gamma, and IL-27, inhibit differentiation of this lineage. Here we review how the nuclear orphan receptor ROR gamma t functions to coordinate the diverse cytokine-induced signals and thus controls Th17 cell differentiation. (C) 2007 Elsevier Ltd. All rights reserved.
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