期刊
EVOLUTIONARY BIOLOGY
卷 34, 期 3-4, 页码 121-129出版社
SPRINGER
DOI: 10.1007/s11692-007-9012-5
关键词
transposable elements; intragenomic conflict; epigenetics; evolution of genetic systems
Increasingly, we regard the genome as a site and source of genetic conflict. This fascinating 'bottom-up' view brings up appealing connections between genome biology and whole-organism ecology, in which populations of elements compete with one another in their genomic habitat. Unlike other habitats, though, a host genome has its own evolutionary interests and is often able to defend itself against molecular parasites. Most well-studied organisms employ strategies to protect their genomes against the harmful effects of genomic parasites, including methylation, various pathways of RNA interference, and more unusual tricks such as repeat induced point-mutation (RIP). These genome defence systems are not obscure biological curiosities, but fundamentally important to the integrity and cohesion of the genome, and exert a powerful influence on genome evolution.
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