期刊
TRAFFIC
卷 8, 期 12, 页码 1687-1694出版社
WILEY
DOI: 10.1111/j.1600-0854.2007.00661.x
关键词
endoplasmic reticulum; membrane protein; mitochondrial outer membrane; protein targeting; SNARE
类别
资金
- NCI NIH HHS [R01CA111987] Funding Source: Medline
- NIEHS NIH HHS [1P30ES014443-01A1] Funding Source: Medline
- PHS HHS [18733] Funding Source: Medline
Intracellular proteins with a carboxy-terminal transmembrane domain and the amino-terminus oriented toward the cytosol are known as 'tail-anchored' proteins. Tail-anchored proteins have been of considerable interest because several important classes of proteins, including the vesicle-targeting/fusion proteins known as SNAREs and the apoptosis-related proteins of the Bcl-2 family, among others, utilize this unique membrane-anchoring motif. Here, we use a bioinformatic technique to develop a comprehensive list of potentially tail-anchored proteins in the human genome. Our final list contains 411 entries derived from 325 unique genes. We also analyzed both known and predicted tail-anchored proteins with respect to the amino acid composition of the transmembrane segments. This analysis revealed a distinctive composition of the membrane anchor in SNARE proteins.
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