期刊
MEDICINAL CHEMISTRY RESEARCH
卷 16, 期 5, 页码 205-212出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-007-9024-9
关键词
antimicrobial activity; MIC; 2,4-dihalofluorobenzenes
The aim of this study was to synthesize and identify 2,4-dihalogenofluorobenzene (or trihalogenobenzene) derivatives by spectroscopic means, H-1-NMR and F-19-NMR. The 2,4-dihalofluorobenzene derivatives considered were 2,4-dichlorofluorobenzene (1), 2-bromo-4-chlorofluorobenzene (2), 2-iodo-4-chlorofluorobenzene(3), 2,5-dichlorofluorobenzene (4), 2-bromo-5-chlorofluorobenzene (5), 2-iodo-5-chlorofluorobenzene (6). The in vitro antibacterial and antifungal activities of trihalogenobenzene derivatives were studied against the bacteria Staphylococcus aureus ATCC 25923 Gram(+), Bacillus cereus ATCC 6633 Gram(+), Micrococcus flavus (clinical isolate) Gram(+), Morgenella morganii (clinical isolate) Gram(-), Escherichia coli ATCC 27853 Gram(-) and fungus Candida albicans (clinical isolate), obtained from the biology departments of the Pamukkale and Gazi Universities. The antibacterial and antifungal activities were measured by minimum inhibition concentration (MIC) method and the disc-diffusion method used to measure zone diameter against Gram-positive and Gram-negative bacteria and fungi. All these bacteria and fungi were studied against antibiotics to compare the zone diameters with the results from our treatments.
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