期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 26, 期 6, 页码 1607-1617出版社
JOHN WILEY & SONS INC
DOI: 10.1002/jmri.21207
关键词
pharmacokinetic analysis; DCE-MRI; head and neck; squamous cell carcinoma; transcytolemmal water exchange
资金
- NCI NIH HHS [R01 CA102756] Funding Source: Medline
Purpose: To investigate the effect of transcytolemmal water, exchange on the dynamic contrast-enhanced (DCE) T-1- weighted MRI of human squamous cell carcinomas of the head and neck (HNSCC). Materials and Methods: Nine patients with HNSCC nodal metastasis underwent pretreatment DCE-MRI with a temporal resolution of 2.5 seconds and a spatial resolution of 1 mm x 1 mm x 5 mm at 1.5T. We used two pharmacokinetic models, for data analysis: generalized kinetic model (GKM) without considering transcytolemmal water exchange and the shutter-speed model (SSM), based on a two-site exchange model for transcytolemmal water exchange. The results were compared in three subgroups of voxels in the tumor depending on the level of contrast enhancement. Results: SSM was found to be a better fit for more than 75% of pixels of all subjects (P < 0.01) in terms of residual size and Bayesian information criterion (BIC). For all three subgroups based on the contrast enhancement, the median K-trans values of SSM were 42% to 55% higher than those of GKM and the median upsilon(e) values of SSM were 116% to 176% larger than those of GKM. The median K-trans and upsilon(e) of two models were found significantly different (P < 0.01). The median tau(i) measured by SSM were from 211 to 364 msec. Conclusion: The effect of transytolemmal water exchange is an important factor that needs to be incorporated for adequate modeling of contrast enhancment dynamics measured by MRI of HNSCC.
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