期刊
BIOMATERIALS
卷 28, 期 34, 页码 5185-5192出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.07.044
关键词
hydrogels; smart biomaterials; self-assembly; hybrid biomaterials; bionanotechnology
资金
- NIBIB NIH HHS [EB005288, EB00251, R01 EB005288-03, R01 EB000251-07, R01 EB005288] Funding Source: Medline
Hydrogels were the first biomaterials developed for human use. The state-of-the-art and potential for the future are discussed. Recently, new designs have produced mechanically strong synthetic hydrogels. Protein-based hydrogels and hybrid hydrogels containing protein domains present a novel advance; such biomaterials may self-assemble from block or graft copolymers containing biorecognition domains. One of the domains, the coiled coil, ubiquitously found in nature, has been used as an example to demonstrate the developments in the design of smart hydrogels. The application potential of synthetic, protein based, DNA based, and hybrid hydrogels bodes well for the future of this class of biomaterials. (C) 2007 Elsevier Ltd. All rights reserved.
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