Evaluation of a bio nano-sensing probe fabricated by focused-ion-beam chemical vapor deposition for single organelle analyses

It is necessary to manipulate and analyze single cells and organelles with high accuracy for a deeper understanding of their biological phenomena. For this purpose, bio nano-tools are very useful. We fabricated a bio nano-sensing probe by using focused-ion-beam chemical vapor deposition (FIB-CVD) and evaluated it using a cell of an Egeria densa leaf. We found that the probe functions as a measurement electrode. This indicates that the bio nano-sensing probe is useful for single organelle analyses.