期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 14, 期 8, 页码 1731-1739出版社
WILEY
DOI: 10.1111/ajt.12743
关键词
Immune modulation; immune regulation; immunobiology; immunosuppression; innate immunity; kidney transplantation; nephrology
资金
- American Society of Nephrology
Autophagy developed into a rapidly expanding field detailing its molecular mechanism and relevance in health and disease. Autophagy is an evolutionarily conserved process that summarizes a pathway in which intracellular material is degraded within the lysosome and where the macromolecular constituents are recycled. This ``self-eating'' process was originally described in a cell under starvation but now numerous studies established autophagy as a cellular response to stress. As a consequence, the autophagy machinery interfaces with most cellular stress-response pathways, including those involved in controlling immune response and inflammation. Autophagy also influences adaptive immunity through its effect on antigen presentation, naive T cell repertoire selection and homeostasis and T-H cell polarization. Data are emerging that dysregulated autophagy has an impact on human pathologies including infectious diseases, cancers, aging and neurodegenerative conditions. This review focuses on recent findings elucidating the ability of autophagy to be of significance in the transplant setting.
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